Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Estrogen-related receptor gamma (ERRγ)
- Target
- ERRγ
- Molecular classification
- Nuclear hormone receptor, Steroid hormone receptor, Transcription factor
01
Overview
Estrogen-related receptor gamma (ERRγ) is a nuclear receptor that functions as a constitutive activator of transcription. It plays a crucial role in regulating oxidative metabolism and angiogenesis. While no endogenous activating ligand has been identified, ERRγ can be modulated by inverse agonists like 4-hydroxytamoxifen and diethylstilbestrol, and by xenoestrogens like Bisphenol A (BPA). ERRγ is implicated in various diseases, including breast cancer, endometrial cancer, metabolic disorders, and cardiovascular diseases, making it an attractive target for drug development.
- Other names
- NR3B3ESRRG
02
Mechanism of action
Constitutive activation of transcription; Modulation via inverse agonists and xenoestrogens.
03
Biological functions
Transcriptional activationRegulation of oxidative metabolismRegulation of angiogenesis
04
Disease associations
Breast cancerEndometrial cancerMetabolic disordersCardiovascular diseases
05
Safety considerations
Potential for endocrine disruption due to interactions with environmental chemicals like BPA.Off-target effects due to structural similarity with other estrogen-related receptors.
06
Interacting drugs
4-hydroxytamoxifen
2 more in the full profile.
Beyond the preview
Go deeper on Estrogen-related receptor gamma (ERRγ).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Estrogen-related receptor gamma (ERRγ).