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ETS-Family Transcription Factors (ETS)
- Target
- ETS
- Molecular classification
- Transcription factor
01
Overview
ETS-family transcription factors are a large family of transcription factors unique to animals, characterized by a conserved DNA-binding domain (ETS domain). They regulate gene expression across diverse biological processes including cellular differentiation, cell cycle control, apoptosis, angiogenesis, and immune function. They are implicated in various diseases, particularly cancer, through gene fusions, deregulated expression, and promotion of tumor progression.
- Other names
- ETS transcription factorsEts-1ESE-1ELK-3PU.1ErgFli-1
02
Mechanism of action
Modulation of gene expression through DNA binding and protein-protein interactions; activation or repression of transcription.
03
Biological functions
Cellular differentiationDevelopmentCell cycle controlCell proliferationCell migrationCell invasionApoptosisAngiogenesisRegulation of immune cell functionRegulation of gene expression
04
Disease associations
CancerEwing's sarcomaEarly pre-B acute lymphoid leukemiaProstate cancerLeukemiasSolid tumorsVascular inflammation
05
Safety considerations
Oncogenic fusion proteinsDeregulated expression in tumorsPromotion of epithelial-mesenchymal transition (EMT)
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