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Target intelligence / Profile preview
ETS variant transcription factor 5 (ETV5)
- Target
- ETV5
- Molecular classification
- Transcription factor, ETS family protein
01
Overview
ETS variant transcription factor 5 (ETV5) is a member of the E26 transformation-specific (ETS) family of transcription factors. It is encoded by the ETV5 gene on chromosome 3q28 in humans. ETV5 is generated in Sertoli cells of the testes where it plays a critical role in spermatogenesis. ETV5 is also recognized for its function in transcriptional regulation in immune cells, notably promoting follicular helper T cell differentiation and influencing osteopontin expression, which has been implicated in the pathogenesis of lupus. Several lines of research associate the orthologs of ETV5 with obesity and bipolar disorder. Although ETV5 is noted for its involvement in cancer biology and other disorders, it is not, at present, a direct therapeutic target or clinically used biomarker[1][2][3][4][5][6].
- Other names
- ETV5ERMETS translocation variant 5ets-related moleculeERM transcription factorets-related protein ERM
02
Mechanism of action
Not applicable (no drugs directly modulate ETV5; mechanisms would be theoretical, related to potential inhibition or modulation of transcription factor activity.)
03
Biological functions
Regulation of gene transcriptionSpermatogenesisFollicular helper T cell differentiationCell proliferation
04
Disease associations
Cancer (implicated in multiple cancer types, mainly via its transcriptional regulatory roles)Obesity (research links ETV5 to obesity, through ortholog studies)Bipolar disorder (ortholog studies suggest involvement)Systemic lupus erythematosus (promotes lupus pathogenesis via osteopontin induction)
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