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Target intelligence / Profile preview
Euchromatic histone-lysine N-methyltransferase 2 (G9a)
- Target
- G9a
- Molecular classification
- Enzyme, Histone modification, Histone-Lysine N-Methyltransferase
01
Overview
EHMT2 (G9a) is a histone methyltransferase enzyme that primarily catalyzes the mono- and di-methylation of lysine 9 on histone H3 (H3K9me1 and H3K9me2), which are epigenetic marks associated with transcriptional repression. It is involved in gene silencing, DNA methylation, cell proliferation, and apoptosis. Dysregulation of EHMT2 is implicated in several cancers.
- Other names
- EHMT2KMT1CBAT8HLA-B associated transcript 8Protein G9a
02
Mechanism of action
Inhibition of histone methyltransferase activity, preventing H3K9 methylation and subsequent gene silencing.
03
Biological functions
Epigenetic regulationDNA methylationGene silencingCell proliferationApoptosis regulationCell cycle controlStress response
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to methylation of other proteins.Unintended consequences of global epigenetic modification.
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