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Eukaryotic Cytosolic Ribosome (80S Ribosome)

Target: 80S Ribosome
Molecular classification: Ribonucleoprotein Complex

Overview

The 80S ribosome is the primary ribonucleoprotein complex responsible for protein synthesis in eukaryotic cells. It consists of two subunits, 40S and 60S, each containing ribosomal RNA (rRNA) and ribosomal proteins. Its main function is to translate mRNA sequences into polypeptide chains. It is a potential therapeutic target, particularly in cancer research, though off-target effects are a concern.

Other names: Human RibosomeAnimal RibosomePlant Ribosome

Mechanism of action

Inhibition of protein synthesis

Biological functions

Protein synthesisTranslation

Disease associations

Cancer (potential target)Other

Safety considerations

Off-target effects due to structural similarity with other ribosomesToxicity related to disruption of protein synthesis

Interacting drugs

Antibiotics (some)

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