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Target intelligence / Profile preview
Eukaryotic Elongation Factor 1A2 (eEF1A2)
- Target
- eEF1A2
- Molecular classification
- Translation factor, GTPase
01
Overview
Eukaryotic elongation factor 1A2 (eEF1A2) is a protein that plays a crucial role in protein synthesis by delivering aminoacyl-tRNAs to the ribosome. It is highly expressed in brain, heart, and skeletal muscle. Beyond translation, eEF1A2 is involved in actin cytoskeleton remodeling and filopodia formation. It is overexpressed in several cancers, making it a potential therapeutic target. Plitidepsin is a drug that targets eEF1A2.
- Other names
- EEF1A2EEF1ALEF-1-alpha-2EF1AHS1STNSTNLEIEE33MRD38eukaryotic translation elongation factor 1 alpha 2
02
Mechanism of action
Binds to eEF1A2, leading to oxidative stress and activation of JNK/p38 MAPK pathways
03
Biological functions
Protein synthesisAminoacyl-tRNA bindingGTP hydrolysisActin cytoskeleton remodelingFilopodia formationTranslation regulation
04
Disease associations
CancerOvarian cancerLung cancerBreast cancerPlasmacytomaMultiple myelomaIntellectual disability
05
Interacting drugs
Plitidepsin
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