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Target intelligence / Profile preview
Eukaryotic Elongation Factor 2 (eEF2)
- Target
- eEF2
- Molecular classification
- GTP-binding protein, Translation Elongation Factor
01
Overview
Eukaryotic elongation factor 2 (eEF2) is a highly conserved, essential protein involved in the process of protein synthesis in eukaryotic cells. It catalyzes the GTP-dependent translocation step during mRNA translation on the ribosome, specifically moving two tRNAs and mRNA after peptidyl transfer on the 80S ribosome. The function of eEF2 is tightly regulated primarily through post-translational modifications like phosphorylation and ADP-ribosylation. Aberrant expression or regulation of eEF2 has been linked with various cancers. Inactivation via bacterial toxins leads directly to disease symptoms due to loss of cellular protein production capacity.
02
Mechanism of action
ADP-ribosylation (Diphtheria toxin, Exotoxin A); Phosphorylation at Thr56 by eEF2K.
03
Biological functions
mRNA translationRibosomal translocationPeptide chain elongation
04
Disease associations
CancerInfection
05
Safety considerations
Inhibition of protein synthesis leading to cell deathPotential for off-target effects due to ubiquitous expression
06
Interacting drugs
Diphtheria toxin
1 more in the full profile.
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