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Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)

Target: GSPT2
Molecular classification: GTP-binding protein, Elongation factor, Release factor

Overview

GSPT2 (GTP-binding protein GSPT2), also known as eukaryotic peptide chain release factor GTP-binding subunit ERF3B, is a protein that functions primarily as a polypeptide release factor involved in translation termination. It acts as a component of the eRF1-eRF3-GTP ternary complex, which mediates translation termination at stop codons. It may also play additional roles in mRNA stability regulation and cell cycle progression. It is highly expressed in certain cancers.

Other names: ERF3BGST2FLJ10441Eukaryotic peptide chain release factor subunit 3bG1 to S phase transition protein 2 homolog

Biological functions

Translation terminationmRNA stability regulationCell cycle progression

Disease associations

Cancer

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