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Eukaryotic Translation Elongation Factor 1 Alpha 1 Pseudogene 40 (EEF1A1P40)

Target
EEF1A1P40
Molecular classification
Other (processed pseudogene)
01

Overview

EEF1A1P40 is a processed pseudogene of the parent gene eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), located in the human genome but not encoding a functional protein product[1][3]. Processed pseudogenes arise from the reverse transcription and integration of mRNA from a parent gene without introns. While most pseudogenes like EEF1A1P40 are considered non-coding and biologically inert, there is growing interest in their possible roles in modulating parent gene activity and disease, including cancer, through regulatory RNA mechanisms[3]. EEF1A1 itself encodes a key GTPase protein that mediates aminoacyl-tRNA delivery to ribosomes during protein biosynthesis and has various non-canonical cellular functions[2][3][4]. The pseudogenes of EEF1A1, including EEF1A1P40, are numerous and typically classified as retropseudogenes distributed throughout the human genome[3]. Specific functional or disease associations for EEF1A1P40 have not been documented in peer-reviewed literature as of the present date.

Other names
EEF1A1P40
02

Mechanism of action

None; not a drug target.

03

Biological functions

None directly; pseudogenes do not encode functional proteins.However, some pseudogenes can regulate their parental gene's expression or be implicated in disease pathogenesis indirectly.
04

Disease associations

Potential regulatory effects in cancer and other diseases have been described for some EEF1A1 pseudogenes, but specific roles for EEF1A1P40 are unreported as of 2024.More broadly, pseudogenes of EEF1A1 have been implicated in various cancers, diabetes, and other conditions.
05

Safety considerations

None specific; pseudogenes do not present therapeutic safety concerns except possibly by influencing gene regulation indirectly in disease contexts.

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