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Target intelligence / Profile preview
Eukaryotic Translation Elongation Factor 1 Alpha 2 (eEF1A2)
- Target
- eEF1A2
- Molecular classification
- Translation factor, GTP-binding protein, Actin-binding protein
01
Overview
Eukaryotic translation elongation factor 1 alpha 2 (eEF1A2) is an isoform of the alpha subunit of the elongation factor-1 complex, which plays a critical role in protein synthesis. It facilitates the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during translational elongation. eEF1A2 is highly expressed in brain, heart, and skeletal muscle. In addition to its role in translation, it binds and bundles actin filaments, influencing cytoskeletal organization. Dysregulation of EEF1A2 is implicated in diseases such as cancer and neurological disorders. Mutations cause severe drug-resistant epilepsy, autism spectrum disorders, and neurodevelopmental delay.
- Other names
- EF-1-alpha-2EF1AHS1STNSTNLStatinEIEE33MRD38
02
Mechanism of action
Currently, there are no approved drugs that directly target eEF1A2. Research is ongoing to explore potential therapeutic strategies.
03
Biological functions
Translational elongationActin binding and bundlingRegulation of apoptosisRegulation of autophagyRegulation of lipid kinase activity
04
Disease associations
OncogenesisEpilepsyAutism spectrum disorderNeurodevelopmental delay
05
Safety considerations
Overexpression can promote tumorigenesis.Mutations can lead to severe neurological disorders.Potential for off-target effects due to high sequence similarity with eEF1A1.
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