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Target intelligence / Profile preview
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A)
- Target
- eIF1A
- Molecular classification
- Translation initiation factor, Protein synthesis machinery, Other
01
Overview
Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is an essential protein that participates in the initiation phase of eukaryotic translation. It is a component of the 43S pre-initiation complex, mediating the recruitment of the 40S ribosomal subunit to the 5' cap of messenger RNAs and facilitating scanning for the start codon as well as assembly of the 80S initiation complex. Mutations in this factor are recurrent in certain cancers, including uveal melanoma and thyroid carcinoma[1][2][5].
- Other names
- EIF1AXEIF1AEIF1AP1EIF4CeIF-1AeIF-4Ceukaryotic translation initiation factor 1A, X-linked
02
Biological functions
Translation initiationmRNA bindingRibosome assemblyRegulation of protein synthesis
03
Disease associations
Cancer, notably thyroid cancer and uveal melanoma
04
Biomarkers
Mutations in EIF1AX as biomarkers in uveal melanoma and thyroid cancer
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