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Target intelligence / Profile preview
Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)
- Target
- EIF2AK1
- Molecular classification
- Serine/threonine-protein kinase, Enzyme
01
Overview
EIF2AK1 is a protein kinase that regulates protein synthesis in response to cellular stress by phosphorylating eIF2α, inhibiting translation initiation. It is activated by oxidative stress, heme deficiency, osmotic shock, and heat shock. Dysregulation is linked to leukoencephalopathy and hypomyelinating leukodystrophy.
- Other names
- HRIHHRIHCRKIAA1369Heme-Regulated Eukaryotic Initiation Factor EIF-2-Alpha Kinase
02
Mechanism of action
Phosphorylation of eIF2α/EIF2S1 at Ser48 and Ser51, preventing recycling of eIF2 and inhibiting ternary complex formation.
03
Biological functions
Regulation of protein synthesisStress responseTranslation initiation regulation
04
Disease associations
Leukoencephalopathy, motor delay, spasticity, and dysarthria syndromeHypomyelinating leukodystrophy type 17
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