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Target intelligence / Profile preview
Eukaryotic Translation Initiation Factor 2 Subunit Alpha (eIF-2α)
- Target
- eIF-2α
- Molecular classification
- Transcription factor, Other
01
Overview
Eukaryotic translation initiation factor 2 subunit alpha (eIF-2α) is a critical regulatory component of the eIF2 heterotrimeric complex, which plays an essential role in the initiation phase of protein synthesis in eukaryotic cells. The α-subunit serves as the main regulatory site for phosphorylation events that control global protein synthesis rates in response to various cellular stresses. Phosphorylation status on serine residue S51 determines whether cells globally suppress new protein synthesis while selectively translating key adaptive genes—a process central both for normal physiology under fluctuating environments and disease states involving chronic cellular stress.
- Other names
- EIF2S1
02
Mechanism of action
Modulation of eIF-2α phosphorylation
03
Biological functions
Regulation of mRNA translationStress responseCell survivalApoptosis
04
Disease associations
CancerNeurodegenerative diseaseViral pathogenesisProteotoxicityNutrient deprivation
05
Safety considerations
Potential for broad impact on protein synthesisOff-target effects on other kinases
06
Biomarkers
eIF-2α phosphorylation levels at Ser51
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