Eukaryotic translation initiation factor 2 subunit gamma (EIF2S3)

Eukaryotic translation initiation factor 2 subunit gamma (EIF2S3) is the largest subunit of the eIF2 complex, a heterotrimeric GTP-binding protein essential in the early steps of eukaryotic protein synthesis. It facilitates the recruitment of the initiator methionyl-tRNA and GTP to the 40S ribosomal subunit, forming the ternary complex, and helps assemble the 43S pre-initiation complex. Perturbations in EIF2S3 function are linked to human diseases such as MEHMO syndrome and neonatal diabetes mellitus, highlighting its role in translation control and cellular homeostasis[1][2][5].

Other names

EIF2gammaEIF2GEIF2Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaEukaryotic translation initiation factor 2 subunit gamma XEukaryotic translation initiation factor 2 subunit 3Eukaryotic translation initiation factor 2GEIF2-Gamma XeIF2γeIF2-gamma XeIF2gXMEHMOMRXSBRKeIF-2gAmental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly and obesity syndrome