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Target intelligence / Profile preview
Eukaryotic translation initiation factor 2B (eIF2B)
- Target
- eIF2B
- Molecular classification
- Guanine nucleotide exchange factor, Enzyme
01
Overview
Eukaryotic translation initiation factor 2B (eIF2B) is a crucial multisubunit protein complex that acts as the guanine nucleotide exchange factor (GEF) for eukaryotic initiation factor 2 (eIF2). It catalyzes the exchange of GDP for GTP on eIF2, regenerating active eIF2-GTP, which is essential for protein synthesis initiation. eIF2B activity is regulated by phosphorylation and other cellular signals, and mutations in eIF2B subunits can cause leukoencephalopathy with vanishing white matter (VWM). It represents a potential therapeutic target in neurodegenerative diseases.
02
Mechanism of action
Guanine nucleotide exchange factor activity; modulation of eIF2 activity.
03
Biological functions
Translation initiationRegulation of protein synthesisGuanine nucleotide exchange
04
Disease associations
Leukoencephalopathy with vanishing white matterNeurodegenerative diseaseAlzheimer’s disease
05
Safety considerations
Dysregulation can lead to neurodegenerative diseases.Potential for off-target effects when modulating translation initiation.
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