Eukaryotic translation initiation factor 3 subunit M (EIF3M)

Eukaryotic translation initiation factor 3 subunit M (EIF3M) is an essential component of the eIF3 multi-protein complex, which is required for initiation of protein synthesis in eukaryotic cells. EIF3M contains a PCI domain and helps define distinct subpopulations of the eIF3 complex, allowing selective binding and translation of specific mRNAs, particularly those involved in cell proliferation, apoptosis, and differentiation. It is vital for recruitment of translation initiation factors and ribosomal subunits, and its function impacts cellular protein homeostasis and quality control. Alterations or dysfunctions in EIF3M and the eIF3 complex are associated with diseases such as cancer and viral infections, making EIF3M a candidate therapeutic target, though it is not yet clinically drugged.

Other names

EIF3MeIF3mHFLB5PCID1GA17PNAS-125hFL-B5FLJ29030TANGO7Fetal lung protein B5PCI domain-containing protein 1transport and golgi organization 7 homolog (Drosophila)dendritic cell protein

Inhibition of protein synthesis initiation (downregulation of eIF3 function) Disruption of mRNA recruitment and ribosome assembly (theoretical/mechanistic studies)