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Eukaryotic Translation Initiation Factor 4A (eIF4A)
- Target
- eIF4A
- Molecular classification
- DEAD-box RNA helicase, Enzyme, Translation Initiation Factor
01
Overview
Eukaryotic translation initiation factor 4A (eIF4A) is a highly conserved, essential protein involved in the initiation phase of eukaryotic mRNA translation. It functions as an ATP-dependent RNA helicase and is a core component of the eIF4F complex, which mediates the recruitment of ribosomes to mRNA by unwinding secondary structures in the 5' untranslated region (UTR) of mRNAs. It has three isoforms: EIF4A1, EIF4A2, and EIF4A3. EIF4A1 and EIF4A2 are functionally interchangeable and essential for cap-dependent translation. EIF4A3 does not substitute for the other isoforms, and may inhibit translation under certain conditions. Its dysregulation has been linked to cancer progression.
- Other names
- EIF4AIEIF4AIIEIF4AIIIDDX2AeIF-4A-I
02
Mechanism of action
ATP-dependent RNA helicase activity; unwinds mRNA secondary structures to facilitate ribosome scanning.
03
Biological functions
mRNA translation initiationRNA helicase activityATP hydrolysisRibosome binding
04
Disease associations
Cancer
05
Safety considerations
Global protein synthesis modulation leading to potential off-target effects.Potential for affecting essential cellular processes
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