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Eukaryotic Translation Initiation Factor 4E (eIF4E)

Target: eIF4E
Molecular classification: Translation initiation factor

Overview

eIF4E (eukaryotic translation initiation factor 4E) is a highly conserved, essential protein in eukaryotes that plays a central role in the initiation of mRNA translation. It is best known as the cap-binding protein that recognizes and binds to the 7-methylguanosine cap structure at the 5' end of most eukaryotic mRNAs. Overexpression or dysregulation leads to increased translation of specific oncogenic mRNAs ("eIF4E-sensitive elements"), contributing to malignant transformation and cancer progression.

Mechanism of action

Disrupts interaction between eIF4E/eIF4G

Biological functions

Translation initiationmRNA bindingNuclear export of mRNA

Disease associations

Cancer

Interacting drugs

4EGI-1

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