Eukaryotic translation initiation factor 4E-binding protein 3 (EIF4EBP3)

Eukaryotic translation initiation factor 4E-binding protein 3 (EIF4EBP3) is a member of the EIF4EBP family that binds eukaryotic translation initiation factor 4E (EIF4E) and regulates its assembly into the eIF4F complex, thereby controlling cap-dependent translation initiation. This regulation occurs through competitive binding: when 4E-BP3 is hypo-phosphorylated, it binds strongly to EIF4E and represses translation; upon phosphorylation by mTOR signaling, it dissociates, enabling translation initiation. EIF4EBP3 also inhibits EIF4E-mediated nuclear mRNA export. Its biological role is closely linked to controlling protein synthesis rates, cellular growth, and potentially tumor suppression. Dysregulation or methylation-induced silencing of EIF4EBP3 has been associated with cancer progression[2][7][8][6].

Other names

4E-BP34EBP3eIF4E-binding protein 3eukaryotic translation initiation factor 4E binding protein 3EIF4EBP3

Modulation of EIF4E activity by phosphorylation/dephosphorylation of EIF4EBP3 controls translation initiation rate; hypo-phosphorylated 4E-BP3 binds and inhibits EIF4E, repressing cap-dependent translation, whereas mTOR-mediated phosphorylation causes dissociation and allows translation initiation[8][2][4].