Eukaryotic translation initiation factor 4E family member 1B (EIF4E1B)

EIF4E1B is a member of the eukaryotic translation initiation factor 4E (eIF4E) family, distinguished by its germ cell-specific expression and role in regulating translation of maternal mRNAs during oogenesis and early embryogenesis[2][3][7]. EIF4E1B binds the 5’ cap of mRNAs with lower affinity than canonical eIF4E, and instead of interacting with eIF4G, associates with the CPEB1 repressor complex and 4E-Transporter to modulate the timing and subset of maternal mRNA translation critical for chromatin accessibility and early zygotic gene activation[2][3]. Structure-function analyses show EIF4E1B shares the core fold and many key cap-binding residues with eIF4E, but has distinct N-terminal and loop regions, altering its biochemical properties and binding partners. Its function is limited primarily to germ cells, unlike the broadly expressed canonical eIF4E, and it has not been directly linked to therapeutic targeting or human disease outside of developmental biology research[2][3][7].

Other names

Eukaryotic translation initiation factor 4E type 1BFLJ36951eIF4E1BeIF4E type 1B

not applicable (No known drugs act directly on EIF4E1B, but translation initiation inhibitors like 4EGI-1 generally act by disrupting eIF4E/eIF4G interactions in related family members[5].)