Eukaryotic translation initiation factor 4H (EIF4H)

Eukaryotic translation initiation factor 4H (EIF4H) is an RNA-binding protein that plays a crucial regulatory role in the initiation phase of protein synthesis by stimulating the ATP-dependent RNA helicase activity of eIF4A[1][5][3][6][7]. EIF4H enhances the binding of eIF4A to ATP and RNA, thereby promoting the unwinding of secondary structures in the 5′-untranslated region (UTR) of mRNAs, which is essential for ribosome scanning and efficient translation initiation[1][5]. The gene encoding EIF4H (located at human chromosome 7q11.23) is deleted in Williams-Beuren syndrome, contributing to the neurodevelopmental, cognitive, and growth deficits observed in this disorder[2][4][7]. EIF4H activity is transcriptionally regulated by the NF-κB pathway in response to cell signaling, linking protein synthesis control to immune and proliferation-related pathways[1]. Although no direct drugs or biomarkers are currently known, EIF4H is considered a potential therapeutic target due to its key role in translation control and cell proliferation[1][5].

Other names

KIAA0038WBSCR1WSCR1eIF-4HWilliams-Beuren syndrome chromosomal region 1 proteinWilliams-Beuren syndrome chromosome region 1