Eukaryotic translation initiation factor 5B (EIF5B)

Eukaryotic translation initiation factor 5B (EIF5B) is an essential GTPase that plays a critical role in the initiation of protein synthesis in eukaryotic cells[1][2][5][6][7]. It catalyzes the joining of the 60S ribosomal subunit to the pre-initiation complex, positioning the initiator methionine-tRNA at the start codon in conjunction with eIF1A and other initiation factors[1][3][5][6]. This precise positioning is vital for the fidelity of translation initiation, ensuring the correct reading frame for mRNA translation[1][3]. EIF5B's activity regulates the formation of the elongation-competent 80S ribosome and is required for cell viability[5]. As a translation factor, dysregulation or mutation of EIF5B can impact cell growth and contribute to disease processes, including cancer[7]. However, there are currently no approved therapeutics directly targeting EIF5B in clinical use.

Other names

IF2KIAA0741eIF-5BDKFZp434I036FLJ10524Translation initiation factor IF-2translation initiation factor IF2eIF5B

Not established for therapeutic drugs; fundamental action is ribosome-dependent GTP hydrolysis promoting initiation complex formation