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EVA1A antisense RNA (EVA1A-AS)
- Target
- EVA1A-AS
- Molecular classification
- Long noncoding RNA, antisense RNA, noncoding RNA
01
Overview
EVA1A antisense RNA (EVA1A-AS) is a long noncoding RNA transcribed in the opposite direction to the EVA1A gene, within its second intron[1]. It suppresses EVA1A gene expression, which itself is an anti-proliferative factor. EVA1A-AS is expressed in certain liver cancer cell lines and its levels are positively correlated with patient survival in hepatocellular carcinoma. Both EVA1A and EVA1A-AS are regulated by the Myc/Max transcription factor complex, frequently dysregulated in cancers. Depletion of EVA1A-AS enhances EVA1A expression, suppresses cell proliferation, and can trigger cell death, indicating its role as a negative regulator of cell death pathways in cancer contexts[1]. There are no known drugs that target EVA1A-AS directly, nor is it considered a "therapeutic target" in the classic sense. EVA1A-AS may have utility as a biomarker for prognosis in HCC.
- Other names
- EVA1A-ASEVA1A-AS1NONHSAG028257.2
02
Biological functions
Regulation of cell proliferationNegative regulation of EVA1A gene expressionModulation of apoptosis/cell death (through EVA1A regulation)Implicated in survival of hepatocellular carcinoma cells
03
Disease associations
CancerHepatocellular carcinoma
04
Biomarkers
EVA1A-AS expression levels may serve as a prognostic marker in HCC for survival correlation
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