Even-skipped homeobox 2 (EVX2)

Even-skipped homeobox 2 (EVX2) is a homeobox transcription factor encoded by the EVX2 gene, located at the 5' end of the HOXD gene cluster on chromosome 2[1][3][5]. It is closely related to the Drosophila even-skipped (eve) gene, which is well-characterized as a pair-rule gene essential for segmental patterning during embryogenesis[2][4][5]. In humans, EVX2 functions as a sequence-specific DNA-binding transcription factor[5] and plays a critical role during limb and neural development. Microdeletions affecting EVX2 and adjacent HOXD genes can lead to limb malformations such as synpolydactyly (the fusion and duplication of digits)[1][5]. While EVX2 is crucial for development, there is currently no evidence supporting its direct involvement as a therapeutic target or its interaction with drugs[1][5]. Its functions mainly relate to development and morphogenesis, and alterations are associated with congenital disorders, not with acquired diseases like cancer or inflammation.

Other names

Homeobox even-skipped homolog protein 2EVX2EVX-2eveeven-skipped homeo box homolog 2even-skipped homeo box 2 (homolog of Drosophila eve)