Ewing sarcoma associated transcript 1 (EWSAT1)

Ewing sarcoma associated transcript 1 (EWSAT1) is a long intergenic non-protein coding RNA (lincRNA) gene located on human chromosome 15. It is specifically upregulated in Ewing sarcoma cells as a downstream target of the EWS-FLI1 fusion transcription factor and plays a critical role in gene repression and maintenance of the oncogenic phenotype in Ewing sarcoma. EWSAT1 functions primarily through interaction with chromatin modifiers and RNA-binding proteins such as HNRNPK, leading to repression of a subset of EWS-FLI1-downregulated genes and facilitating tumor cell proliferation and growth in vitro. Its expression is highly specific to Ewing sarcoma relative to other tumors, making it a candidate biomarker for this disease, but it is not considered a classical therapeutic target like a receptor, enzyme, or transporter. No approved drugs directly target EWSAT1, and its functional or therapeutic modulation remains an area of research interest

Other names

FLJ33768LINC00277NCRNA00277TMEM84long intergenic non-protein coding RNA 277testicular tissue protein Li 207transmembrane protein 84

acts as a non-coding RNA mediator of gene repression downstream of the EWS-FLI1 fusion transcription factor, interacts with RNA-binding proteins (e.g., HNRNPK) to modulate gene expression