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Target intelligence / Profile preview
Ewing sarcoma breakpoint region 1–Friend leukemia virus integration 1 fusion protein (EWS-FLI)
- Target
- EWS-FLI
- Molecular classification
- Transcription factor, Fusion protein
01
Overview
The EWS-FLI fusion protein is a hallmark driver mutation in most cases of classic Ewing sarcoma, acting as a potent aberrant transcription factor that rewires cellular growth control pathways through both direct changes in gene regulation and indirect effects on mRNA processing. Its unique structure—combining disordered activation domains with ordered DNA-binding motifs—underlies its pathological function in cancer biology.
- Other names
- EWS/FLIEWS-FLI1
02
Mechanism of action
Inhibition of EWS-FLI function; disruption of EWS-FLI interaction with DNA or other proteins.
03
Biological functions
Cell proliferationCell survivalGene expression regulationAlternative splicing
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of EWS-FLI inhibitorsDevelopment of resistance to EWS-FLI inhibitors
06
Biomarkers
EWS-FLI fusion transcript (detection via RT-PCR or FISH)
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