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Target intelligence / Profile preview
Ewing tumor-associated antigen 1 activator of ATR kinase (ETAA1)
- Target
- ETAA1
- Molecular classification
- Other, Protein, ATR kinase activator
01
Overview
Ewing tumor-associated antigen 1 activator of ATR kinase (ETAA1) is a protein involved in the cellular response to replication stress and DNA damage, where it accumulates at sites of DNA damage and stalled replication forks, promoting fork progression and integrity. ETAA1 directly stimulates ATR kinase activity by interacting with the RPA complex, independently of the canonical ATR activator TOPBP1, and regulates a subset of ATR targets. ETAA1 participates in positive regulation of protein serine/threonine kinase activity, cell cycle phase transition, and replication fork processing. Disease associations include certain immunodeficiencies and restless legs syndrome, and it is implicated in cancer biology as a part of the DNA damage response pathway[1][4][3].
- Other names
- Ewing's tumor-associated antigen 1ETAA16Ewing's tumor-associated antigen 16ATR kinase activatorETAA1_HUMANQ9NY74
02
Mechanism of action
Activation of ATR kinase activity independently of TOPBP1 by recruitment to stalled replication forks via interaction with replication protein A (RPA) complex
03
Biological functions
DNA damage responseReplication stress responseReplication fork progressionPositive regulation of protein serine/threonine kinase activityRegulation of cell cycle phase transitionReplication fork processing
04
Disease associations
CancerImmunodeficiency (including Immunodeficiency 26 with or without neurologic abnormalities)Restless legs syndrome
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