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Excitatory Amino Acid Receptor (EAAR)
- Target
- EAAR
- Molecular classification
- Receptor, Ionotropic Receptor, Metabotropic Receptor, Ligand-gated Ion Channel, G protein-coupled receptor
01
Overview
Excitatory amino acid receptors are a class of neurotransmitter receptors in the central nervous system (CNS) that mediate excitatory synaptic transmission. They primarily respond to endogenous amino acids, most notably glutamate and aspartate. These receptors play crucial roles in synaptic plasticity, learning, memory, and neurodevelopment. Overactivation can lead to excitotoxicity and cell death.
- Other names
- Glutamate ReceptorAspartate ReceptoriGluRmGluR
02
Mechanism of action
Modulation of neuronal excitability via ion flow or second messenger systems
03
Biological functions
Excitatory neurotransmissionSynaptic plasticityLearningMemoryNeurodevelopmentSignal transduction
04
Disease associations
StrokeHead traumaEpilepsyViral encephalopathyAmyotrophic lateral sclerosis (ALS)Neurodegenerative diseaseExcitotoxicity
05
Safety considerations
ExcitotoxicityOveractivation leading to neuronal death
06
Interacting drugs
Glutamate
7 more in the full profile.
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