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Exocyst complex component 3 (EXOC3)
- Target
- EXOC3
- Molecular classification
- Other (exocyst complex component; not a receptor, enzyme, transporter, transcription factor, histone modifier; belongs to a multi-protein tethering complex)
01
Overview
Exocyst complex component 3 is a cytosolic protein encoded by the EXOC3 gene in humans. It is a core member of the exocyst complex, which consists of eight unique subunits (EXOC1–8) that work together to tether secretory vesicles for targeted fusion at specific sites of the plasma membrane. This process is essential for directed exocytosis, maintenance of epithelial cell surface polarity, and regulation of cell trafficking pathways. In platelets, EXOC3 controls granule secretion and the trafficking of glycoprotein receptors, influencing thrombosis and hemostatic function, but does not exhibit redundancy with its paralogs in this cell type[1][2][3][5][6]. Deficiency in EXOC3 impairs vesicle trafficking dynamics, leading to functional defects in cellular secretion and signaling pathways.
- Other names
- EXOC3SEC6SEC6L1Sec6Sec6pSec6-like 1Exocyst complex component Sec6
02
Biological functions
Vesicle traffickingExocytosisDocking of exocytic vesicles to plasma membraneMaintenance of epithelial cell surface polarityPlatelet granule secretionGlycoprotein receptor trafficking in platelets
03
Disease associations
ThrombosisHemostasisPotential relevance in cancer cell lines (essentiality screens)Other (cell polarity defects are implicated in cancer)
04
Safety considerations
Disruption of EXOC3 may cause defects in vesicle trafficking, granule secretion, and hemostasis; thus, targeting may impact platelet function and thrombosisNo therapeutics currently target EXOC3; safety profile as a drug target is not defined
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