Exocyst complex component 3-like protein 2 (EXOC3L2)

Exocyst complex component 3-like protein 2 (EXOC3L2) is a cytosolic protein component associated with the exocyst complex, an evolutionarily conserved multiprotein complex essential for tethering secretory vesicles to specific sites on the plasma membrane prior to exocytosis, thereby regulating vesicle trafficking, cell polarity, and migration[1][2][3]. In endothelial cells, EXOC3L2 is required for proper migration in response to vascular endothelial growth factor A (VEGFA) by supporting VEGFR2 trafficking and signaling[1][2]. It interacts with core exocyst complex elements such as EXOC4, and its expression is increased in vascular tissue during developmental angiogenesis[1]. While it shares some structural homology with EXOC3, EXOC3L2 carries distinct regulatory domains and appears important for certain actin-dependent processes like filopodia formation and directed chemotaxis in response to growth factors[1]. There is no current evidence supporting EXOC3L2 as a direct therapeutic target or as the subject of any approved or investigational drugs[1][2][3]. Its biological role is specialized within cell movement and vesicle targeting rather than receptor signaling, enzymatic conversion, or drug transport. Associations with disease are indirect, mainly from gene locus studies and not from functional or clinical investigations.

Other names

XTP7FLJ36147BMRSHBV X-transactivated gene 7 proteinHBV XAg-transactivated protein 7protein 7 transactivated by hepatitis B virus X antigen (HBxAg)