Exocyst complex component 3-like protein 4 (EXOC3L4)

Exocyst complex component 3-like protein 4 (EXOC3L4) is a protein-coding gene believed to encode a subunit of the exocyst complex, an evolutionarily conserved octameric protein complex essential for tethering post-Golgi secretory vesicles to the plasma membrane prior to SNARE-mediated fusion, thus playing a critical role in exocytosis and vesicle trafficking. EXOC3L4 is predicted to contribute to SNARE binding and exocyst localization and is thought to function in processes fundamental to secretion in eukaryotic cells. Rare variants in EXOC3L4 have been implicated in altered glucose metabolism in the brain in the context of Alzheimer’s disease and may play a role in rare congenital disorders such as Hermansky-Pudlak syndrome 7 and Seckel syndrome. The protein does not have evidence of being a direct therapeutic target, nor are there known small-molecule drugs or biomarker applications established in the literature to date[1][2][3][4][5].

Other names

C14orf73SEC6-like protein C14orf73exocyst complex component 3 like 4