Exocyst complex component 4 (EXOC4)

Exocyst complex component 4 (EXOC4) is a protein encoded by the *EXOC4* gene in humans and is a core subunit of the exocyst complex[1][2][5][7]. The exocyst is an evolutionarily conserved, hetero-octameric tethering complex involved in targeting exocytic vesicles to precise docking sites on the plasma membrane, and is required for functions such as membrane fusion, exocytosis, endocytosis, autophagy, cell polarization, and epithelial cell surface polarity[1][2][3][7]. EXOC4 and other exocyst subunits coordinate with the actin cytoskeleton and small GTPases to ensure fidelity of vesicular trafficking and membrane assembly[2][3][7]. This protein is not commonly considered a direct therapeutic target or receptor, but is crucial for cellular organization and transport processes. Mutations in EXOC4 have been associated with diseases such as Meckel syndrome type 1 and disorders of the peripheral nervous system, reflective of its key role in cellular architecture and trafficking[2].

Other names

EXOC4SEC8SEC8L1Sec8pexocyst complex component 4