Exocyst complex component 6B (EXOC6B)

Exocyst complex component 6B is a protein encoded by the human EXOC6B gene and is an integral subunit of the evolutionarily conserved exocyst complex[1][3][7][8]. The exocyst complex is a hetero-octameric structure composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84, which regulates targeted exocytosis by docking exocytic vesicles at specified fusion sites on the plasma membrane in eukaryotic cells[2][3][4][7][8]. EXOC6B (and its yeast/rat ortholog Sec15) is essential for this vesicle trafficking process, which underlies key cellular events such as cell growth, polarity establishment, and neuronal outgrowth[2][3]. Mutations or disruptions in EXOC6B have been linked to developmental syndromes such as spondyloepimetaphyseal dysplasia with joint laxity, as well as intellectual disability and developmental delay, likely reflecting the broader importance of vesicle trafficking in organismal development and cellular function[3]. There is currently no evidence to classify EXOC6B as a direct therapeutic target or to associate it with approved drugs or biomarker status in clinical settings.

Other names

SEC15L2SEC15B