Exocyst complex component 7 (EXOC7)

Exocyst complex component 7 (EXOC7), also known as Exo70, is a subunit of the exocyst complex, an evolutionarily conserved, octameric protein complex required for targeting and docking of post-Golgi secretory vesicles at designated sites of the plasma membrane prior to membrane fusion[1][3][5]. The exocyst plays a fundamental role in polarized exocytosis, governing the delivery of proteins and lipids to specific membrane subdomains critical for processes such as epithelial morphogenesis, neuronal outgrowth, and cell migration[5][9]. EXOC7 interacts with other exocyst components (e.g., EXOC4/SEC8) and GTPases (e.g., RHOQ), and is implicated in cellular functions spanning vesicle trafficking, cell polarity, cytokinesis, and possibly pre-mRNA splicing[1][5]. Mutations in EXOC7 have been linked to severe neurodevelopmental disorders characterized by microcephaly, brain atrophy, seizures, and developmental delay, underscoring its essential role in cortical development and neuron survival[9]. While the exocyst is central to cellular logistics and disease pathogenesis, EXOC7 itself is not considered a classic therapeutic target like a receptor or enzyme, nor are there currently known drugs that act through this subunit.

Other names

Exo70KIAA1067YJL085WExo70pBLOM4Exocyst complex component Exo702-5-3pEX070EXO70EXOC1NEDSEBA