Target intelligence / Profile preview

Exoribonuclease

Molecular classification
Enzyme
01

Overview

Exoribonucleases are a class of ribonuclease enzymes that degrade RNA molecules by removing terminal nucleotides from either the 5' end or the 3' end of an RNA strand. They play essential roles in RNA metabolism, including quality control, degradation, processing, and maturation of various types of RNAs such as messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and microRNAs. They are found in all domains of life—bacteria, archaea, and eukaryotes—and can exist as single proteins or as part of multi-protein complexes like the exosome complex in eukaryotes.

02

Mechanism of action

Inhibition of exoribonuclease activity, leading to RNA stabilization or altered RNA processing.

03

Biological functions

RNA turnoverRNA degradationmRNA decaytRNA processingrRNA maturationNonsense-mediated decay (NMD)Gene silencingTranscription termination
04

Disease associations

CancerInfectionNeurodegenerative diseaseDevelopmental disorders
05

Safety considerations

Potential for off-target effects due to broad substrate specificity.Disruption of essential RNA metabolic pathways.

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