Exoribonuclease 1 (ERI1)

Exoribonuclease 1 (ERI1) is an evolutionarily conserved 3'-5' exoribonuclease of the DEDDh family that catalyzes the trimming of 3' overhangs in structured RNA substrates, most notably the 3' ends of histone mRNAs and 5.8S ribosomal RNA, and also regulates small RNA turnover such as siRNA and microRNA. It is involved in both the maturation of ribosomal RNA and the regulated degradation of histone mRNAs following DNA replication, contributing to gene silencing, chromatin regulation, and proper cell-cycle progression. ERI1 also modulates RNA interference pathways, limiting or fine-tuning siRNA responses in multiple organisms. Dysregulation or mutation of ERI1 is associated with human genetic diseases (such as spondyloepimetaphyseal dysplasia), but no drug interactions or direct cancer links are well described at present.

Other names

3'-5' exoribonuclease 13'EXOTHEX1HEXO3'HEXO3'-5' exonuclease ERI1Eri-1 homologHistone mRNA 3'-end-specific exoribonucleaseHistone mRNA 3'-exonuclease 1Protein 3'hExoHXALSEMDGCSEMDGSthree prime histone mRNA exonuclease 1three prime mRNA exonuclease 1

3'-5' exoribonucleolytic degradation of RNA substrates (e.g., histone mRNAs, siRNAs, 5.8S rRNA)