Exosome complex component 6 (EXOSC6)

Exosome complex component 6 (EXOSC6) is a non-catalytic core subunit of the **RNA exosome complex**, an evolutionarily conserved multi-protein machinery responsible for 3' to 5' degradation and processing of a wide variety of RNA substrates in both the nucleus and cytoplasm[1][2][5]. EXOSC6 contributes structurally as part of the exosome's core "Exo-9" complex, binding RNA and scaffolding the assembly of the catalytic subunits, but lacks intrinsic exonuclease activity itself[1][2]. The exosome complex is critical for **maturation of stable RNAs** (such as rRNA, snRNA, and snoRNA), removal of aberrant or unstable mRNAs (especially those containing AU-rich elements), and overall RNA surveillance—maintaining proper gene expression and preventing accumulation of faulty RNAs[1][2][5]. Expression patterns of exosome complex genes, including EXOSC6, have been linked to patient prognosis in certain cancers, notably **mantle cell lymphoma**, and may serve as expression biomarkers in oncology research[7]. There are no known drugs targeting EXOSC6 specifically, nor direct mechanism-of-action or safety data related to pharmacological modulation of this protein[1][7]. **Notes:** - EXOSC6 is not considered a classical druggable "therapeutic target" (such as a receptor or enzyme) but plays a fundamental role in RNA metabolism[1][5]. - Direct disruption of the exosome complex core, including EXOSC6, would likely have profound effects on cell viability due to the essential functions of RNA surveillance and processing[1][5]. - EXOSC6 is highly conserved and homologous to the yeast Mtr3 protein[1][2].

Other names

Exosome complex component MTR3MTR3hMtr3hMtr3pMtr3pEAP4p11mRNA transport regulator 3 homologExosome component 6exosome complex exonuclease MTR3homolog of yeast mRNA transport regulator 3