Exosome component 5 (EXOSC5)

Exosome component 5 (EXOSC5) is a structural, non-catalytic subunit of the multi-protein RNA exosome complex, a highly conserved ribonucleoprotein machinery essential for the processing, maturation, and decay of a broad spectrum of nuclear and cytoplasmic RNAs. EXOSC5 does not possess intrinsic ribonuclease activity but forms part of the central ring that scaffolds and regulates access to catalytic subunits, impacting gene expression quality control, defense response to viral RNA, and cell cycle regulation. Dysregulation of EXOSC5 expression is implicated in carcinogenesis, particularly in solid and hematologic cancers, through its modulation of cell proliferation via AKT and STAT3 signaling pathways. Genetic variants affecting EXOSC5 function cause complex syndromic diseases marked by neurological, cardiac, and developmental abnormalities, highlighting both its clinical relevance and safety challenges in therapeutic targeting.

Other names

Exosome complex component RRP46CML28RRP46hRrp46pRrp46pRRP41BMGC12901p12BChronic myelogenous leukemia tumor antigen 28Ribosomal RNA-processing protein 46CABAC

Indirect: Suppress EXOSC5-driven cancer cell proliferation by inhibiting downstream signaling (AKT and STAT3). Pathway targeting: Disruption of AKT and STAT3 phosphorylation to block cell cycle progression.