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Target intelligence / Profile preview
Expanded Adipose-Derived Mesenchymal Stem Cells (eASC)
- Target
- eASC
- Molecular classification
- Mesenchymal Stem Cells, Stromal Cells
01
Overview
Expanded adipose-derived mesenchymal stem cells are multipotent stromal/stem cells from fat tissue with robust expansion capability in vitro. They offer multilineage differentiation potential along with strong paracrine-mediated immunomodulatory effects—making them attractive candidates for regenerative medicine applications involving soft-tissue repair or modulation of inflammation/metabolism.
- Other names
- Adipose-Derived Mesenchymal Stem CellsASCsAdipose-derived stem cells
02
Mechanism of action
Paracrine signaling via growth factors and cytokines; immunomodulation through cytokine secretion and macrophage polarization; tissue regeneration via angiogenesis and wound healing.
03
Biological functions
Multilineage differentiationImmunomodulationTissue RegenerationParacrine signalingAngiogenesisWound healing
04
Disease associations
Soft-tissue injuryInflammatory diseasesMetabolic disordersObesityDiabetes
05
Safety considerations
Donor characteristics (obesity, diabetes) may impair cell functionReduced anti-inflammatory activity in cells from certain donors
06
Biomarkers
CD73+CD90+CD105+CD45-CD34-CD31-CD31-/CD34+
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