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Exportin-1 (XPO1)

Target: XPO1
Molecular classification: Nuclear export receptor, Transporter

Overview

Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is a highly conserved eukaryotic nuclear export receptor. It mediates the transport of proteins and RNAs from the nucleus to the cytoplasm, playing a central role in nucleo-cytoplasmic trafficking. It is a therapeutic target, particularly in cancer, and its inhibition can lead to cancer cell death or sensitization to other therapies.

Other names: CRM1CC112

Mechanism of action

Inhibition of XPO1-mediated nuclear export, leading to retention and activation of tumor suppressor proteins in the nucleus.

Biological functions

Nuclear-cytoplasmic transportCell cycle regulationApoptosisRibosome biogenesisProteostasisImmune regulationRNA export

Disease associations

CancerInfection

Interacting drugs

Selinexor

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