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Exportin-6 (XPO6)
- Target
- XPO6
- Molecular classification
- Nuclear transport receptor, Exportin, Importin β superfamily member, Other
01
Overview
Exportin-6 (XPO6) is a member of the importin β superfamily of nuclear transport receptors, functioning specifically as a nuclear export receptor that mediates the export of actin-profilin complexes from the nucleus to the cytoplasm in a Ran-GTP–dependent manner[1][2][3]. It recognizes profilin-bound monomeric actin (G-actin), promoting its nuclear exclusion and thus regulating the balance of actin between nucleus and cytoplasm[2][3]. Exportin-6 is conserved across higher eukaryotes and is required for the maintenance of nuclear actin homeostasis, with implications for cellular structure and function but no direct disease association currently established[2][3].
- Other names
- Exportin 6XPO6KIAA0370RANBP20Exp6FLJ22519Ran-binding protein 20EXP6exportin-6ran-binding protein 20
02
Biological functions
Nuclear export of actin-profilin complexesRegulation of actin polymerization in the nucleusMaintenance of nuclear actin homeostasisOther
03
Disease associations
Other (no direct association with major disease categories documented in current literature; however, regulation of actin dynamics may impact cell cycle function and genomic integrity)
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