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Target intelligence / Profile preview
External NADH Oxidase Type 2 (Nox-2)
- Target
- Nox-2
- Molecular classification
- Enzyme, Oxidase, Dehydrogenase
01
Overview
External NADH oxidase type 2 (Nox-2 or NDH-2) is an enzyme that catalyzes the oxidation of NADH by transferring electrons to molecular oxygen or quinones. This process regenerates NAD(+) from NADH, which is essential for cellular redox balance and energy metabolism. It is located on the external face of the mitochondrial inner membrane in eukaryotes and is membrane-associated in prokaryotes. Unlike Nox-1, Nox-2 primarily forms water as a product and is resistant to complex I inhibitors like rotenone, capsaicin and piericidin A. Nox-2 plays a critical role in maintaining the cellular pool of oxidized nicotinamide adenine dinucleotide (NAD(+)).
- Other names
- Type II NAD(P)H dehydrogenaseNDH-2
02
Mechanism of action
N/A
03
Biological functions
Redox homeostasisNADH oxidationNAD(+) regenerationAerobic metabolism
04
Interacting drugs
Rotenone
2 more in the full profile.
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