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External nasal nerve

Molecular classification
Other (Peripheral sensory nerve; not a molecular target such as a receptor, enzyme, or transporter)
01

Overview

The **external nasal nerve** is a terminal sensory branch of the anterior ethmoidal nerve, itself derived from the nasociliary branch of the ophthalmic division (V1) of the trigeminal nerve. It emerges at or near the keystone area between the lower border of the nasal bone and upper lateral cartilage. The external nasal nerve supplies sensation to most of the skin on top and at the tip of your nose but does not innervate most alar regions around your nostrils. This small peripheral sensory nerve is clinically relevant because it is frequently injured during surgical procedures such as rhinoplasty, resulting in temporary or persistent numbness over its distribution area[1][2][3][4]. Additional notes: - The external nasal nerve is an anatomical structure rather than a molecular therapeutic target like receptors or enzymes. - There are no known drugs that specifically interact with this structure. - It does not serve as a biomarker for disease nor play direct roles in major disease categories beyond local trauma-related symptoms. If you are seeking information about drug targets for pharmacological intervention, this entry would be considered incorrect ("is_incorrect": true), since it refers to an anatomical peripheral sensory branch rather than a canonical druggable molecule/receptor.

Other names
External nasal branch of anterior ethmoidal nerveRamus nasalis externus nervi ethmoidalis anterioris (Latin)
02

Biological functions

Sensory innervation of the skin over the dorsum and tip of the nose[1][2][3][4]
03

Disease associations

Other (May be involved in postoperative numbness after rhinoplasty or trauma to the external nose[2])
04

Safety considerations

Risk of injury during nasal surgery, especially rhinoplasty, leading to temporary or permanent numbness at the nasal tip and dorsum[2]

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