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Target intelligence / Profile preview
Extracellular DNA (exDNA)
- Target
- exDNA
- Molecular classification
- Nucleic acid
01
Overview
Extracellular DNA (exDNA) refers to DNA located outside of cell membranes. It is found in various environments like ecosystems, biofilms, and bodily fluids, originating from lysed cells or active secretion. It plays roles in structural support, antimicrobial defense, genetic exchange, and cell signaling. Clinically, it serves as a non-invasive diagnostic tool and potential therapeutic target.
- Other names
- eDNACell-free DNACirculating cell-free nucleic acids
02
Mechanism of action
N/A
03
Biological functions
Structural supportBiofilm formationAntimicrobial defenseHorizontal gene transferCell signalingImmune modulation
04
Disease associations
CancerInfectionInflammationOther
05
Safety considerations
Excessive or dysregulated release of extracellular nucleic acids can lead to disease
06
Biomarkers
Liquid biopsy for cancer detectionPrognosis assessmentMonitoring treatment response or disease progression
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