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Extracellular DNA in Airway Secretions (DNA)
- Target
- DNA
- Molecular classification
- Nucleic Acid, DNA
01
Overview
Extracellular DNA present within airway secretions originating from host cells (neutrophils, epithelial cells) and microorganisms. Elevated levels contribute to increased viscosity and elasticity of mucus, impairing mucociliary clearance and promoting inflammation and infection. It is a therapeutic target for mucolytic agents such as dornase alfa.
- Other names
- Airway DNASputum DNAExtracellular DNAeDNA
02
Mechanism of action
Enzymatic degradation of extracellular DNA, reducing mucus viscosity
03
Biological functions
Structural component of mucusImmune modulationInflammationViscosity regulation
04
Disease associations
Cystic FibrosisChronic BronchitisAsthmaBronchiectasisInfectionAirway obstruction
05
Safety considerations
Potential for immune response against degraded DNAPossible alterations in microbiome composition
06
Interacting drugs
Dornase alfa (rhDNase)
07
Biomarkers
Sputum DNA concentrationAirway secretion DNA concentration
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