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Extracellular Fluid Compartment
- Molecular classification
- Body Fluid, Physiological Compartment
01
Overview
The extracellular fluid (ECF) compartment refers to all body fluids located outside the cells of multicellular organisms. It comprises the interstitial fluid (IF) surrounding tissue cells, plasma within blood vessels, transcellular fluid (e.g., cerebrospinal fluid, synovial fluid), and lymph. The ECF facilitates nutrient, gas, and waste exchange between blood and cells, maintains electrolyte balance, regulates pH, and ensures proper volume status. Disruptions can lead to clinical conditions such as dehydration/overhydration or electrolyte disturbances.
02
Biological functions
Nutrient transportWaste removalElectrolyte balancepH regulationVolume regulationCellular communication
03
Disease associations
DehydrationOverhydrationElectrolyte imbalanceEdemaAcid-base disordersKidney diseaseHeart failure
04
Safety considerations
Fluid overloadElectrolyte abnormalitiesAcid-base disturbancesDrug interactions affecting fluid balance
05
Interacting drugs
Diuretics
4 more in the full profile.
06
Biomarkers
Serum sodiumSerum potassiumSerum chlorideBicarbonateBlood urea nitrogen (BUN)CreatinineOsmolalityHematocrit
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