Extracellular matrix–cell surface receptors and tissue components (ECM-cell surface receptors)

Extracellular matrix–cell surface receptors and tissue components refers to a broad biological category encompassing the interactions between the extracellular matrix (ECM) and various cell-surface proteins, as defined in the Reactome pathway database (R-HSA-446728). This group includes major receptor families such as integrins, syndecans, and discoidin domain receptors, as well as ECM structural proteins like collagens, laminins, and fibronectin (Source: UniProt). These interactions are fundamental to cell adhesion, migration, and the transmission of biochemical and mechanical signals that regulate cell survival and differentiation (Source: StatPearls, PMID: 30020607). In pathological states, dysregulation of these components contributes significantly to cancer metastasis, tissue fibrosis, and chronic inflammatory diseases (Source: Nature Reviews Cancer, PMID: 24903765). While the category itself is not a single drug target, many of its individual members, particularly integrins, are critical therapeutic targets for treating cardiovascular, autoimmune, and oncological conditions (Source: PubMed, PMID: 28839151).

Other names

Cell-extracellular matrix interactionsECM-receptor interactionExtracellular matrix organizationCell-matrix adhesion

Antagonism of cell-surface receptors (primarily integrins) to inhibit binding to extracellular matrix ligands, thereby modulating cell adhesion and downstream signaling pathways.