Extracellular matrix and associated cell-surface partners (ECM)

The extracellular matrix (ECM) and associated cell-surface partners represent a vast network of extracellular macromolecules and their corresponding receptors that provide structural and functional integrity to tissues (Frantz et al., 2010, J Cell Sci). This complex assembly, often referred to as the matrisome, includes core components like collagens, elastins, and laminins, as well as associated receptors such as integrins and syndecans that bridge the extracellular environment to the intracellular cytoskeleton (Hynes & Naba, 2012, Cold Spring Harb Perspect Biol). Beyond providing a physical scaffold, the ECM serves as a dynamic signaling hub that regulates essential cellular processes including survival, proliferation, and migration by sequestering growth factors and transducing mechanical cues (Reactome, R-HSA-1474244). In disease states, the ECM is often pathologically remodeled; for instance, excessive deposition leads to fibrosis, while enzymatic degradation facilitates cancer cell invasion and metastasis (Lu et al., 2012, J Cell Biol). Although the ECM is a broad biological category rather than a single molecular entity, its individual constituents are high-value therapeutic targets for a wide range of clinical indications, from cardiovascular disease to oncology (Naba et al., 2016, BMC Cancer).

Other names

Extracellular matrixMatrisomeECM-associated proteinsCell-matrix interactomeExtracellular matrix organization

Modulation of cell-matrix adhesion, enzymatic degradation of structural components, and inhibition of integrin-mediated signaling.