Extracellular matrix of articular cartilage (ECM (contextual, but not standard for a molecular target))

The extracellular matrix of articular cartilage is a highly specialized, composite structure that makes up about 90% of cartilage tissue volume, providing its biomechanical properties and resilience[2][3]. It consists primarily of type II collagen fibrils for tensile strength; proteoglycans (notably aggrecan) for water retention and compressive resistance; and a variety of non-collagenous proteins such as cartilage oligomeric matrix protein (COMP), fibronectin, and lubricin for structural integrity and lubrication[1][2]. This matrix is organized into pericellular, territorial, and interterritorial regions, which have different molecular compositions and functions[3]. ECM integrity is key for joint health, with its breakdown playing a central role in the pathogenesis of osteoarthritis and other degenerative joint diseases[1][2]. While therapies aim to preserve or restore ECM, it is not a specific "drug target" in the traditional molecular sense.

Other names

Articular cartilage ECMcartilage extracellular matrix

Not applicable as a discrete molecular target; however, drugs may act by inhibiting ECM degradation (such as MMP inhibitors) or enhancing ECM synthesis (anabolic growth factors)