Extracellular matrix remodeling enzyme

Extracellular matrix remodeling enzymes are a functional group of secreted enzymes—including proteases (such as matrix metalloproteinases, serine proteases, cysteine proteases), and oxidases (such as lysyl oxidase)—that orchestrate the degradation, processing, and crosslinking of extracellular matrix components. These enzymes are essential for tissue development, wound healing, immune cell migration, and organ morphogenesis; however, their dysregulation drives diverse pathological processes such as cancer metastasis, fibrosis, and chronic inflammation. While they are established as important therapeutic targets, drug development faces substantial challenges due to the lack of target specificity and the critical role these enzymes play in normal tissue maintenance[1][4][5][6].

Other names

Matrix remodeling enzymeECM remodeling enzymeECM modifying enzymeMatrix metalloproteinase (as a subset)

Inhibition of ECM proteolysis (e.g., MMP inhibitors); Modulation of ECM cross-linking (e.g., lysyl oxidase inhibitors)